Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis Article

Full Text via DOI: 10.1016/j.pcad.2021.07.005 Web of Science: 000713012700010
International Collaboration

Cited authors

  • Beltran-Garcia J, Osca-Verdegal R, Nacher-Sendra E, Cardona-Monzonis A, Sanchis-Gomar F, Carbonell N, Pallardo FV, Lavie CJ, Garcia-Gimenez JL

Abstract

  • The mechanisms occurring during sepsis that produce an increased risk of cardiovascular (CV) disease (CVD) are poorly understood. Even less information exists regarding CV dysfunction as a complication of sepsis, particularly for sepsis-induced cardiomyopathy. However, recent research has demonstrated that non-coding RNAs, includ-ing microRNAs, long non-coding RNAs, and circular RNAs, playa crucial role in genetic reprogramming, gene reg-ulation, and inflammation during the development of CVD. Here we describe experimental findings showing the importance of non-coding RNAs mediating relevant mech-anisms underlying CV dysfunction after sepsis, so contributing to sepsis-induced cardiomyopathy. Importantly, non-coding RNAs are critical novel regulators of CVD risk factors. Thus, they are potential candidates to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other CVD events occurring after sepsis and set the basis to design novel therapeutic strategies. (c) 2021 Elsevier Inc. All rights reserved.

Authors

Publication date

  • 2021

Published in

International Standard Serial Number (ISSN)

  • 0033-0620

Number of pages

  • 8

Start page

  • 70

End page

  • 77

Volume

  • 68