An intimate knowledge of the lymphatic drainage of the head and neck is needed by the clinician examining and diagnosing patients with lesion of this region. It is considered that approximately 150 to 300 lymph nodes are located in the neck region. The classification of cervical lymph nodes by Rouviere has long been most widely referenced in textbooks and articles because it covers most of the lymph nodes of the head and neck region. Anatomical review of the lymphatic system of the head and neck helps surgeons understand and treat the patients who have any cancers and cancer metastasis in and around the head and neck regions. Regardless, comprehensive review of the lymphatic system of the head and neck has been rarely discussed. This paper details the anatomy of the lymphatics of these regions by reviewing related publications, books, official reports from the academic society and also describes the clinical manifestations and levels used in staging of the various lymph nodes with illustrations and computed tomographic images.