Transfusion of allogeneic blood products is given for correction of coagulation deficits and for the improvement in oxygencarrying capacity or delivery. Blood transfusion has become safer following the advancement in blood testing using state-ofthe-art viral assays; however, there continues to exist a variety of noninfectious transfusion risks that still remain and that cannot be entirely eliminated. Research is now directed towards understanding these lesser-known, but serious transfusionrelated complications. This purpose of this review is to discuss a serious noninfectious cause of acute lung injury, transfusionrelated acute lung injury (TRALI), which occurred in 2 recent cases in the intensive care unit, and to review the current literature of this syndrome.
