Histoplasmosis is a common infection in endemic areas among patients with a compromised immune system. Disseminated infection frequently involves the gastrointestinal system, but esophageal involvement with symptoms is rare. We present a case of an immune compromised patient presenting with dysphagia and odynophagia secondary to esophageal histoplasmosis. We discuss the clinical presentation, differential diagnosis, diagnostic approaches, and available treatments.
