Wilk, Anna; Waligorski, Piotr; Lassak, Adam; Vashistha, Himanshu; Lirette, David; Tate, David; Zea, Arnold H.; Koochekpour, Shahriar; Rodriguez, Paulo; Meggs, Leonard G.; Estrada, John J.; Ochoa, Augusto; Reiss, Krzysztof
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are the products of incomplete combustion of organic materials, which are present in cigarette smoke, deep-fried food, and in natural crude oil. Since PAH-metabolites form DNA adducts and cause oxidative DNA damage, we asked if these environmental carcinogens could affect transforming potential of the human Polyomavirus JC oncoprotein,
