The exact number of male to female transsexuals is not known; however, sex reassignment has become a headline news topic.; Individuals who have undergone sex reassignment via hormonal and/or surgical means must undergo appropriate cancer screening.; Prostate cancer is the most common noncutaneous malignancy in men, however, its appropriate screening guidelines have become controversial.; As the potential for an increased number of male to female transsexuals develops, so should guidelines for individuals who have had sex reassignment. (C) 2016 Elsevier Inc. All rights reserved.