Seaquist, E. R.; Blonde, L.; McGill, J. B.; Heller, S. R.; Kendall, D. M.; Bumpass, J. B.; Pompilio, F. M.; Grant, M. L.
Abstract
AimTo evaluate the effect of final HbA(1c) levels on the incidences of hypoglycaemia in participants with type 1 diabetes treated with inhaled Technosphere (R) Insulin or subcutaneous insulin aspart, reported in alignment with the International Hypoglycaemia Study Group recommendations. Methods In the randomized, phase 3, multicentre AFFINITY-1 study, adults (N = 375) who had type 1 diabetes for >= 12 months and an HbA(1c) level of 58-86 mmol/mol (7.5-10.0%) were randomized to receive basal insulin plus either inhaled Technosphere Insulin or subcutaneous insulin aspart. This was a post-hoc regression analysis on a subset (N = 279) of the randomized AFFINITY-1 cohort for whom baseline and end-of-treatment HbA(1c) values were reported. Primary outcome measures were incidence and event rates for levels 1, 2 and 3 hypoglycaemia, respectively defined as blood glucose levels of <= 3.9 mmol/l, Participants treated with Technosphere Insulin experienced statistically significantly fewer level 1 and 2 hypoglycaemic events and a lower incidence of level 3 hypoglycaemia than participants treated with insulin aspart. The lower rate of hypoglycaemia with Technosphere Insulin was observed across the range of end-of-treatment HbA(1c) levels. Technosphere Insulin was associated with higher rates of hypoglycaemia 30-60 min after meals, but significantly lower rates 2-6 h after meals. Conclusions Participants using Technosphere Insulin experienced clinically non-inferior glycaemic control and lower hypoglycaemia rates across a range of HbA(1c) levels compared with participants receiving insulin aspart. : NCT01445951.
