Insulin glargine 300 U/mLversus first-generation basal insulin analogues in insulin-naive adults with type 2 diabetes: 12-month outcomes ofACHIEVEControl, a prospective, randomized, pragmatic real-life clinical trial Article

Full Text via DOI: 10.1111/dom.14116 PMID: 32538550 Web of Science: 000552653300001
Industry Collaboration International Collaboration

Cited authors

  • Meneghini, Luigi; Blonde, Lawrence; Gill, Jasvinder; Dauchy, Arnaud; Bacevicius, Andrius; Strong, Jodi; Bailey, Timothy S.

Abstract

  • Aim:To report the effectiveness and safety of insulin glargine 300 U/mL (Gla-300) versus standard-of-care basal insulin analogues (SOC-BI) at 12 months in the ACHIEVE Control trial, which is a prospective pragmatic randomized real-life study in insulin-naive adults with type 2 diabetes (T2D). Methods A total of 3304 insulin-naive adults with T2D and glycated haemoglobin (HbA1c) concentration of 64 to 97 mmol/mol (8.0% to 11.0%) after >= 1 year of treatment with two or more antihyperglycaemic agents were randomized to Gla-300 or SOC-BI. Key secondary endpoints included HbA1c target attainment without documented symptomatic (<= 3.9 mmol/L [<= 70 mg/dL]) or severe hypoglycaemia at 12 months. Results At 12 months, 26.1% (Gla-300) and 23.7% (SOC-BI) of adults achieved HbA1c targets without documented symptomatic (<= 3.9 mmol/L [<= 70 mg/dL]) or severe hypoglycaemia (odds ratio [OR] 1.14, 95% confidence interval [CI] 0.97-1.35); 33.0% and 29.5%, respectively, achieved HbA1c targets without documented symptomatic (<3.0 mmol/L [<54 mg/dL]) or severe hypoglycaemia (OR 1.19, 95% CI 1.02-1.38). The OR for HbA1c target achievement was 1.15 (95% CI 0.99-1.34), and favoured Gla-300 versus SOC-BI for absence of documented symptomatic or severe hypoglycaemia at 12 months for both <= 3.9 mmol/L (<= 70 mg/dL; OR 1.21, 95% CI 1.05-1.40) and < 3.0 mmol/L (<54 mg/dL; OR 1.26, 95% CI 1.07-1.48). Conclusion Gla-300 tended to be associated with lower hypoglycaemia risk than SOC-BI in real-world clinical practice during the 12-month follow-up.

Authors

Publication date

  • 2020

Published in

International Standard Serial Number (ISSN)

  • 1462-8902