Lineage-specific regulation of PD-1 expression in early-stage hepatocellular carcinoma following 90yttrium transarterial radioembolization - Implications in treatment outcomes Article

Full Text via DOI: 10.1016/j.ejca.2023.113442 Web of Science: 001122705900001

Cited authors

  • Núñez KG, Sandow T, Gimenez J, Hibino M, Fort D, Cohen AJ, Thevenot PT

Abstract

  • Background: Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths in the world. Liver-directed therapies, including (90)Yttrium (Y-90) radioembolization, play an integral role in the management of HCC with excellent response rates. This has led to clinical trials of immunotherapy in combination with Y-90. Elevated PD-1 expression and lymphopenia were recently shown as risk factors for disease progression in early-stage HCC treated with liver-directed therapies. The aim of this study was to investigate PD-1 expression dynamics in bridge/downstage to transplant in HCC patients receiving first-cycle Y-90 and evaluate the impact of these changes on response rates and time-to-progression (TTP).Methods: Patients with HCC receiving first-cycle Y-90 as a bridge to liver transplantation (n = 99) were prospectively enrolled. Blood specimens were collected before Y-90 and again during routine imagining follow-up to analyze PD-1 expression via flow cytometry. Complete and objective response rates (CR and ORR) were determined using mRECIST.Results: In 84/88 patients with available follow-up imaging, 83% had a localized ORR with 63% having localized CR. For overall response, 71% and 54% experienced ORR and CR, respectively. Post-Y-90 PD-1 upregulation in CD8 + associated with HCC progression and decreased TTP. Treatment with Y-90 was associated with an anticipated significant post-treatment drop in lymphocytes (P < 0.001) that was independent of PD-1 expression for either CD4(+) or CD8(+) T cells (P = 0.751 and P = 0.375) and not associated with TTP risk. The change in lymphocytes was not correlated with PD-1 expression following treatment nor TTP.Conclusions: Elevated PD-1 expression on peripheral T cells is associated with increased risk of HCC progression and shorter time to progression in bridging/downstaging to transplant HCC patients undergoing first-cycle Y-90. Treatment-induced lymphopenia was not associated with treatment response, or increased progression risk, suggesting this anticipated adverse event does not impact short-term HCC outcomes.

Authors

Publication date

  • 2023

Published in

International Standard Serial Number (ISSN)

  • 0959-8049

Number of pages

  • 7

Volume

  • 196